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Bioinformatics, an overview

Rutgers Biochemistry Society
November 19, 2003

A conversation between Mahesh Yaragatti, President of the Society, and Bruce Byrne, PhD, Associate Director for Education, The Informatics Institute of UMDNJ

Mahesh: What is BioInformatics?

Depends on whom you ask...

  • NIH
    • Bioinformatics
      • Research, development, or application of computational tools and approaches for expanding the use of biological, medical, behavioral or health data, including those to acquire, store, organize, archive, analyze, or visualize such data.
    • Computational Biology
      • The development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological, behavioral, and social systems.
  • David Mount: Bioinformatics: Sequence and Genome Analysis. Cold Spring Harbor Laboratory Press.
    • Bioinformatics
      • An interdisciplinary field involving biology, computer science, mathematics, and statistics to analyze biological sequence data, genome content, and arrangement, and to predict the function and structure of macromolecules
  • Bruce Byrne
      • Using computers to systematically create new knowledge for biology


Mahesh: What about graduate program?

Our audience is narrowly targeted. We're looking for students who understand biology and biochemistry; who are experimentalists; who need to use the rich applications available; who will be contributing to the databases; who need to evaluate the next generation of applications and databases; who need to communicated to their partners in bioinformatics: computer science, mathematics, and statistics.

The web is full of descriptions of programs. The following are (or appear to be) alive at the moment. There are a lot of moribund programs still listed by reputable institutions... and some not reputable. Take care.

  • Check that the web sites are up to date and active.
  • Make certain that courses listed are indeed being offered.
  • Talk to students in the programs.

An unscientific survey of offerings:

UMDNJ (Other)

UW - Madison

Rutgers

Yale

Penn

University of the Sciences (Philadelphia)

Boston University

Johns Hopkins

George Mason University

Mahesh: What kind of jobs in academia/industry?

The job boards and journals suggest that they're plentiful. But, as you look at the listings, note which employers are seeking candidates labeled "bioinformaticists" and which are looking for more traditional titles with skills in bioinformatics.

Mahesh: What undergraduate majors would give a good background?

  • Biology
  • Chemistry
  • Computer Science
  • Mathematics
  • Bioinformatics (??)

The big question now is how the next generation of people who use computers to create new knowledge in biology will be trained. Will it be in a new discipline ("bioinformatics") or will we depend on classical fields of study and incorporate new skills into those fields?

The critical characteristic of the next generation of scientists may not be based in which of the fields they are trained but that they be curious and open about companion fields and that they have sufficient skills that they can speak the language of their collaborators.

Mahesh: What's the future of BioInformatics?

There are a couple of ways to approach this question. Look at what the literature and conferences are saying

Use novel methods

More questions?

Bruce Byrne

(856) 757-7788

byrne@umdnj.edu

 

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